Fibrin-targeted and pH-responsive liposomes for synergistic thrombolysis and thrombotic microenvironment reprogramming

Xinyuan Li; Lingying Chen; Rui Sun; Lishan Xiong; Jinhan Yan; Qiongfan Liu; Chunrong Yang; Zuowen Zhang; Chenhui Wang

doi:10.1039/d6nr00983b

January 1, 2026Nanoscale

Fibrin-targeted and pH-responsive liposomes for synergistic thrombolysis and thrombotic microenvironment reprogramming

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Key Points

The aim is to enhance thrombolytic therapy by developing targeted liposomes that respond to pH changes.
Developed tLipo@UA liposomes targeting fibrin.
Tested the response of liposomes to varying pH levels.
Evaluated thrombolytic efficacy in thrombotic microenvironments.
tLipo@UA showed increased effectiveness in thrombus breakdown.
Demonstrated reduced bleeding risks compared to traditional therapies.
Exhibited significant reprogramming of the thrombotic microenvironment.

Implication

Innovative liposomes improve thrombolysis in thrombotic environments, indicating potential for safer treatments.

Abstract

Thrombolytic therapy, exemplified by tissue plasminogen activator, is often constrained by a short half-life, non-specific action, and bleeding risks. To address these limitations, we developed tLipo@UA, a fibrin-targeted and pH-responsive...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69e07cfa2f7e8953b7cbdfdd https://doi.org/10.1039/d6nr00983b

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Fibrin-targeted and pH-responsive liposomes for synergistic thrombolysis and thrombotic microenvironment reprogramming

Key Points

Implication

Abstract

Discussion

Cite This Study

Fibrin-targeted and pH-responsive liposomes for synergistic thrombolysis and thrombotic microenvironment reprogramming

Key Points

Implication

Abstract

Discussion

Cite This Study

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