Co-Assembled Ion-pair Complex Nanoparticles from Tranexamic Acid and Metformin with Enhanced Transdermal Efficacy against UVB-Induced Pigmentation

Key Points

• The aim is to explore the efficacy of co-assembled nanoparticles from tranexamic acid and metformin for reducing UVB-induced pigmentation.
• Developed ion-pair complex nanoparticles from tranexamic acid and metformin.
• Conducted in vitro and in vivo assessments of transdermal delivery efficacy.
• Measured pigmentation levels post-UVB exposure.
• Nanoparticles showed significantly enhanced transdermal absorption.
• Reduced UVB-induced pigmentation was observed in treated samples.
• Indicated potential for lower melanoma risk through effective pigmentation management.