What question did this study set out to answer?

The aim is to explore the efficacy of co-assembled nanoparticles from tranexamic acid and metformin for reducing UVB-induced pigmentation.

April 16, 2026Journal of Materials Chemistry B0 citations

Co-Assembled Ion-pair Complex Nanoparticles from Tranexamic Acid and Metformin with Enhanced Transdermal Efficacy against UVB-Induced Pigmentation

XZXinglong ZhangHubei University of Technology MJMengdie JiHubei University of Technology MLMengjie LiuHubei University of Technology

Key Points

The aim is to explore the efficacy of co-assembled nanoparticles from tranexamic acid and metformin for reducing UVB-induced pigmentation.
Developed ion-pair complex nanoparticles from tranexamic acid and metformin.
Conducted in vitro and in vivo assessments of transdermal delivery efficacy.
Measured pigmentation levels post-UVB exposure.
Nanoparticles showed significantly enhanced transdermal absorption.
Reduced UVB-induced pigmentation was observed in treated samples.
Indicated potential for lower melanoma risk through effective pigmentation management.

Abstract

The aesthetic effect of skin pigmentation caused by ultraviolet radiation and its increased risk of melanoma have received more attention. Non-invasive transdermal delivery has been widely recognized, but the transdermal...

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