Chemical chaperone TUDCA rescues Insulin-mediated vascular relaxation via ER stress inhibition in diabetic rat model

Key Points

• This research aims to explore the effects of TUDCA on insulin-mediated vascular relaxation in a diabetic rat model.
• Diabetic rat model was used for the study.
• TUDCA was administered to assess its effects on vascular relaxation.
• Markers of ER stress, eNOS, Akt, and IRS-1 expression were measured.
• Insulin-mediated relaxation was impaired by 56.7% in diabetic rats compared to controls.
• TUDCA treatment improved vascular relaxation responses by 6.2%.
• TUDCA significantly reduced ER stress markers and restored endothelial marker expression.