Chemical chaperone TUDCA improves insulin responses in diabetic rats, indicating potential therapeutic benefits.
Insulin-mediated relaxation was impaired in diabetic rats (-56.7%) compared to controls (0%), accompanied by elevated ER stress markers and reduced eNOS, Akt, and IRS-1 expression. TUDCA treatment improved relaxation responses (-6.2%) significantly reduced ER stress markers and restored the expression of endothelial markers.
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Mustapha et al. (2026) studied this question.
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