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December 1, 1996Journal of Cardiovascular Pharmacology

Chronic Treatment In Vivo with Dimethylthiourea, a Hydroxyl Radical Scavenger, Prevents Diabetes-Induced Endothelial Dysfunction

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Why the study?

Does chronic treatment with dimethylthiourea prevent endothelial dysfunction in streptozotocin-induced diabetic rats?

Population

Lewis strain rats made diabetic by intravenous injection of streptozotocin

Comparison

Dimethylthiourea 50 mg/kg daily intraperitoneal… vs Diabetic rats not receiving DMTU

Design

Preclinical

Follow-up

8 weeks

Authors

GPGalen M. PieperMedical College of WisconsinWSWolfgang SiebeneichMedical College of WisconsinARAllan M. RozaMedical College of Wisconsin

Discussion

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Implication

Supports hydroxyl radical scavenging to preserve endothelial function in diabetic rats; leaves open clinical translation of antioxidant strategies.

Structured PICO

Does chronic treatment with dimethylthiourea prevent endothelial dysfunction in streptozotocin-induced diabetic rats?

P
Population
Lewis strain rats made diabetic by intravenous injection of streptozotocin
I
Intervention
Dimethylthiourea (DMTU) 50 mg/kg daily intraperitoneal injections beginning 72 h after streptozotocin and continuing throughout 8 weeks of diabetes
C
Comparator
Diabetic rats not receiving DMTU
O
Outcome
Endothelium-dependent relaxation to acetylcholine in isolated descending thoracic aortassurrogate

Chronic in vivo treatment with the hydroxyl radical scavenger dimethylthiourea prevents diabetes-induced endothelial dysfunction in rats without altering glycemic control, highlighting the role of oxidative stress in vascular complications.

Cite This Study

Pieper et al. (1996) studied this question.

synapsesocial.com/papers/6a849a30da9d2319e77c0fcahttps://doi.org/10.1097/00005344-199612000-00002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peroxidative Stress in Diabetic Blood Vessels: Reversal by Pancreatic Islet Transplantation1995 · 107 citations
  2. 2Amelioration by L-Arginine of a Dysfunctional Arginine/Nitric Oxide Pathway in Diabetic Endothelium1995 · 162 citations
  3. 3Impaired Contraction and Endothelium-Dependent Relaxation in Isolated Resistance Vessels from Patients with Insulin-Dependent Diabetes Mellitus1994 · 141 citations
  4. 4Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.1993 · 1,133 citations
  5. 5The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of <i>α</i>1-antiproteinase against inactivation by hypochlorous acid1987 · 173 citations