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September 1, 2000Circulation ResearchOpen Access

Treatment With Dimethylthiourea Prevents Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction in Mice

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Why the study?

Does dimethylthiourea prevent left ventricular remodeling and failure after experimental myocardial infarction in mice?

Population

Mice with experimental myocardial infarction (MI) and sham-operated mice

Comparison

Dimethylthiourea administered daily via… vs MI animals without DMTU and sham-operated animals

Design

Preclinical

Follow-up

4 weeks

Authors

SKShintaro KinugawaHTHiroyuki TsutsuiSHShunji Hayashidani

Discussion

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Overview

Supports antioxidant strategies to limit post-MI remodeling in mice; leaves open translation to human HF therapy.

Structured PICO

Does dimethylthiourea prevent left ventricular remodeling and failure after experimental myocardial infarction in mice?

P
Population
Mice with experimental myocardial infarction (MI) and sham-operated mice
I
Intervention
Dimethylthiourea (DMTU) administered daily via intraperitoneal injection for 4 weeks
C
Comparator
MI animals without DMTU and sham-operated animals
O
Outcome
Left ventricular remodeling and failure (fractional shortening, LV chamber diameter, thickness of noninfarcted myocardium)surrogate

In a mouse model of myocardial infarction, the hydroxyl radical scavenger dimethylthiourea attenuated left ventricular remodeling and improved contractile function.

Cite This Study

Kinugawa et al. (2000) studied this question.

synapsesocial.com/papers/6a21436fa2a97f3a085ae04ehttps://doi.org/10.1161/01.res.87.5.392
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