Key result
TUDCA improves endothelial dilation and reduces arterial stiffness in type 2 diabetic mice.
Why the study?
The importance of endoplasmic reticulum stress in diabetic vascular dysfunction is unclear.
Does tauroursodeoxycholic acid improve arterial stiffness and endothelial dysfunction in type 2 diabetic mice?
Population
Type 2 diabetic db/db mice and control C57BL/6J mice
Comparison
Tauroursodeoxycholic acid (TUDCA) treatment vs no treatment
Design
Preclinical study with ex vivo and chronic in vivo administration
Follow-up
4 weeks
Authors
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TUDCA may improve vascular function in diabetic mice; leaves open clinical translation of ER stress inhibition.
Does tauroursodeoxycholic acid improve arterial stiffness and endothelial dysfunction in type 2 diabetic mice?
Inhibition of ER stress with TUDCA improves endothelial dysfunction and reduces arterial stiffness in a mouse model of type 2 diabetes, suggesting a potential therapeutic target for diabetic vascular dysfunction.
Battson et al. (2017) studied Type 2 diabetes. Tauroursodeoxycholic acid (TUDCA) vs. Control C57BL/6J mice / untreated DB mice was evaluated on Arterial stiffness and endothelial dysfunction. Acute incubation and chronic administration of TUDCA improved endothelium-dependent dilation in mesenteric arteries and reduced arterial stiffness in type 2 diabetic mice.