Key result
Taurine treatment significantly improved left ventricular systolic and diastolic function and ameliorated myocardial oxidative stress in STZ-induced diabetic rats.
Why the study?
Does taurine improve myocardial function and reduce oxidative stress in a rat model of type I diabetes?
Population
60 male Sprague-Dawley rats (4 groups of 15), including a streptozotocin (STZ)-induced type I diabetes model.
Comparison
Taurine orally administered daily for 8 weeks. vs Untreated diabetic rats and non-diabetic controls.
Design
Preclinical, assigned randomly
Follow-up
8 weeks
Authors
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Taurine shows benefit in a rat model of diabetic cardiomyopathy; hypothesis-generating for human translation pending clinical trials.
Does taurine improve myocardial function and reduce oxidative stress in a rat model of type I diabetes?
Taurine ameliorates myocardial function and oxidative stress in a rat model of diabetic cardiomyopathy.
Wang et al. (2013) studied Diabetic cardiomyopathy (n=60). Taurine vs. Untreated diabetic rats (STZ group) and healthy controls was evaluated on Left ventricular hemodynamic analysis and myocardial oxidative stress. Taurine treatment significantly improved left ventricular systolic and diastolic function and ameliorated myocardial oxidative stress in STZ-induced diabetic rats.
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