Why the study?
Does tanshinone IIA pretreatment improve cardiac function and reduce myocardial apoptosis in experimental diabetic cardiomyopathy?
Population
Streptozocin (STZ) induced diabetic rats (n=60) and healthy Sprague-Dawley (SD) rats (n=20)
Comparison
Tanshinone IIA or TSN plus HOE140 vs Saline and healthy SD rats as control
Design
Preclinical, randomized
Authors
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Hypothesis-generating for tanshinone IIA in diabetic cardiomyopathy; prospective human trials needed before clinical consideration.
Does tanshinone IIA pretreatment improve cardiac function and reduce myocardial apoptosis in experimental diabetic cardiomyopathy?
Tanshinone IIA exerts cardioprotective effects in experimental diabetic cardiomyopathy via the kinin B2 receptor-Akt-GSK-3β dependent pathway.
Sun et al. (2011) studied this question.
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