Key result
Tadalafil significantly reduced myocardial infarct size following ischemia/reperfusion injury (23.2% vs 47.8%, p<0.01) and decreased fasting glucose and inflammatory cytokines in diabetic mice.
Why the study?
Does tadalafil reduce infarct size and improve metabolic and inflammatory parameters in diabetic mice?
Does tadalafil reduce infarct size and improve metabolic and inflammatory parameters in diabetic mice?
Absolute Event Rate: 23.2% vs 47.8%
p-value: p=<0.01
Tadalafil therapy ameliorates circulating inflammatory cytokines, improves fasting glucose, and reduces infarct size following ischemia-reperfusion injury in a diabetic mouse model.
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Should not change practice; hypothesis-generating for tadalafil in diabetic ischemia-reperfusion models.
Varma et al. (2012) studied Diabetes and Myocardial Ischemia/Reperfusion Injury (n=20). Tadalafil vs. 10% DMSO (vehicle) was evaluated on Infarct size (% of risk area) (p=<0.01). Tadalafil significantly reduced myocardial infarct size following ischemia/reperfusion injury (23.2% vs 47.8%, p<0.01) and decreased fasting glucose and inflammatory cytokines in diabetic mice.
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