Key result
Tadalafil pretreatment significantly reduced cardiac injury, inflammatory markers, and apoptosis compared to control in male rats with myocardial ischemia/reperfusion injury (P<0.05).
Why the study?
The study was conducted to assess the potential protective effect of Tadalafil on myocardial ischemia reperfusion injury induced by LAD ligation.
Does Tadalafil reduce myocardial ischemia/reperfusion injury in a rat model?
RCT (n=28)
randomized into 4 groups
Does Tadalafil reduce myocardial ischemia/reperfusion injury in a rat model?
Tadalafil demonstrates cardioprotective effects against ischemia/reperfusion injury in a rat model by reducing inflammation and apoptosis.
Should not change clinical practice; leaves open translation of tadalafil cardioprotection to human ischemia/reperfusion injury.
The objective of this study is to assess the potential protective effect of Tadalafil on myocardial ischemia reperfusion injury induced by LAD ligation, 28 male rats were randomized into 4 groups (7 rats per group); Sham, rats underwent the same anesthetic and surgical procedure except for LAD ligation; control, rats underwent LAD ligation for 30 minutes and reperfusion for 2 hours; vehicle, rats treated with 10% DMSO, the Tadalafil solvent 30 minutes before the ligation; Tadalafil group, rats pretreated with Tadalafil1mg/kg i.p 30 minutes before ligation. In control group, as compared with sham, tissue TNF-α, IL-6, IL-10, caspase-3 and BAX, plasma cTn-T and serum MDA significantly increased (P<0.05), while serum GSH significantly decreased (P<0.05). Histopathologically, control group showed a significant cardiac injury (P<0.05) compared with sham group. Tadalafil significantly counteracted (P<0.05) the increase of TNF-α, IL-6, caspase-3 and BAX and counteracted the increase in plasma cTn-T and serum MDA. Tadalafil produces a significant elevation (P<0.05) in cardiac IL-10 and serum GSH with significant reduction in (P<0.05) cardiac injury. In We concluded that Tadalafil attenuates myocardial I/R injury in male rats through interfering with inflammatory reactions and apoptosis .
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Ali A. Ahmed (2020) conducted an RCT in myocardial ischemia reperfusion injury (n=28). Tadalafil vs. control and vehicle was evaluated on cardiac injury, inflammatory markers, and apoptosis (p=<0.05). Tadalafil pretreatment significantly reduced cardiac injury, inflammatory markers, and apoptosis compared to control in male rats with myocardial ischemia/reperfusion injury (P<0.05).
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