June 25, 2024International Journal of Molecular SciencesOpen Access

Tauroursodeoxycholic Acid (TUDCA) Relieves Streptozotocin (STZ)-Induced Diabetic Rat Model via Modulation of Lipotoxicity, Oxidative Stress, Inflammation, and Apoptosis

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Authors

NMNema A. MohamedAlexandria University MIMohammed T. IthmilMustansiriyah University AEAyman I. ElkadyKing Abdulaziz University

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Implication

Randomized trial demonstrates that tauroursodeoxycholic acid reduces glycemic and inflammatory markers in diabetic rats, suggesting therapeutic potential for diabetes management.

Key Points

Tauroursodeoxycholic acid significantly reduced blood glucose and insulin resistance while restoring tissue glycogen in diabetic rats, relieving streptozotocin-induced metabolic damage.
Treatment in fifteen diabetic rats lowered ceramide synthase and elevated glucagon-like peptide-1, accompanied by marked reductions in apoptosis markers caspase-3 and p53 expression.
Findings support targeting lipotoxicity and oxidative stress in diabetes management, though evidence remains limited to a small rat model requiring further clinical translation.

Cite This Study

Mohamed et al. (2024) studied this question.

synapsesocial.com/papers/68e634d8b6db6435875c6e90 https://doi.org/10.3390/ijms25136922

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Implication

Randomized trial demonstrates that tauroursodeoxycholic acid reduces glycemic and inflammatory markers in diabetic rats, suggesting therapeutic potential for diabetes management.

Tauroursodeoxycholic Acid (TUDCA) Relieves Streptozotocin (STZ)-Induced Diabetic Rat Model via Modulation of Lipotoxicity, Oxidative Stress, Inflammation, and Apoptosis

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Implication

Key Points

Cite This Study

Tauroursodeoxycholic Acid (TUDCA) Relieves Streptozotocin (STZ)-Induced Diabetic Rat Model via Modulation of Lipotoxicity, Oxidative Stress, Inflammation, and Apoptosis

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Implication

Key Points

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