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This research examines the effects of ursodeoxycholic acid on blood glucose and metabolic indexes in rats with type 2 diabetes.

August 2, 2026Discover Endocrinology and MetabolismOpen Access

Effects of ursodeoxycholic acid on blood glucose and related metabolic indexes in type 2 diabetes rats

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XBXiu-Ping BaiShanxi Medical University 魏L魏领燕 WEI Ling-yanShanxi Medical University YHYu-Feng HanShanxi Medical University

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Implication

Randomized trial shows ursodeoxycholic acid improves blood glucose and metabolic indexes in type 2 diabetes rats, indicating potential therapeutic benefits.

Key Points

This research examines the effects of ursodeoxycholic acid on blood glucose and metabolic indexes in rats with type 2 diabetes.
Male SD rats (n=30) were divided into three groups: a control group, a type 2 diabetes group, and a UDCA intervention group.
Oral glucose tolerance tests were performed and biochemical parameters were measured, including insulin, C-peptide, triglycerides, and total cholesterol levels.
Gene expression related to lipid and glucose metabolism in the liver was analyzed using real-time PCR.
In Group B (type 2 diabetes), OGTT AUC increased, while insulin and C-peptide levels decreased, and liver TG and TC levels were elevated.
In Group C (UDCA intervention), all metabolic indexes improved compared to Group B, indicating a reduction in glucose levels and related abnormalities.
Gene expression linked to lipid and glucose metabolism showed positive changes in response to UDCA treatment.

Cite This Study

Bai et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeaaf1b0468a7eeab3048 https://doi.org/10.1007/s44417-026-00024-5

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Implication

Randomized trial shows ursodeoxycholic acid improves blood glucose and metabolic indexes in type 2 diabetes rats, indicating potential therapeutic benefits.

Effects of ursodeoxycholic acid on blood glucose and related metabolic indexes in type 2 diabetes rats

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Implication

Key Points

Cite This Study

Effects of ursodeoxycholic acid on blood glucose and related metabolic indexes in type 2 diabetes rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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