What question did this study set out to answer?

The aim is to analyze plasma antibodies and proteomic changes over time during vaccination and SARS-CoV-2 infection.

April 21, 2026Open Access

Antibody profiling and plasma proteomics in SARS-CoV-2 infection: a pilot study

Key Points

The aim is to analyze plasma antibodies and proteomic changes over time during vaccination and SARS-CoV-2 infection.
Single-subject longitudinal analysis of plasma samples
Utilized DIA-LC-MS/MS for protein identification
Compared proteomic data across pre-vaccination, post-dose 1, post-dose 2, and post-infection intervals.
Identified 1502 proteins in plasma samples
Minimal proteomic changes observed post-vaccination
Distinct expression changes noted after SARS-CoV-2 infection.

Abstract

We present a pilot, single-subject longitudinal analysis of plasma antibodies and proteome dynamics across 310 days spanning COVID-19 vaccination and subsequent SARS-CoV-2 infection. Serial plasma samples were analyzed by DIA-LC-MS/MS, identifying 1502 proteins. Comparative analyses across key intervals (pre-vaccination, post-dose 1, post-dose 2, and post-infection) showed minimal proteomic shifts after vaccination but distinct, coordinated expression changes after SARS-CoV-2 infection.

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Cite This Study

Fukuda et al. (Sun,) studied this question.

synapsesocial.com/papers/69e71423cb99343efc98d811 https://doi.org/https://doi.org/10.1038/s41598-026-48765-z

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