Pilot study investigates antibody and protein changes post-vaccination and SARS-CoV-2 infection, suggesting distinct responses.
We present a pilot, single-subject longitudinal analysis of plasma antibodies and proteome dynamics across 310 days spanning COVID-19 vaccination and subsequent SARS-CoV-2 infection. Serial plasma samples were analyzed by DIA-LC-MS/MS, identifying 1502 proteins. Comparative analyses across key intervals (pre-vaccination, post-dose 1, post-dose 2, and post-infection) showed minimal proteomic shifts after vaccination but distinct, coordinated expression changes after SARS-CoV-2 infection.
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Fukuda et al. (2026) studied this question.
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