Rational Design of η⁶-Arene Ru(II) Complexes for Amyloid-β Targeting: Influence of Coordination Lability and Aromaticity

Key Points

• The study aims to explore how the design of η⁶-arene Ru(II) complexes can affect their interaction with amyloid-β peptides.
• Investigated a series of η⁶-arene Ru(II) complexes for their ability to modulate amyloid-β aggregation.
• Analyzed the effects of coordination lability and aromaticity on binding interactions.
• Utilized various coordination chemistry techniques to assess supramolecular effects.
• Certain Ru(II) complexes significantly reduced amyloid-β aggregation.
• The degree of coordination lability was correlated with the efficacy of amyloid-β targeting.
• Increased aromaticity in complexes enhanced binding to amyloid-β peptides.