ANOCA was associated with higher left ventricular end-diastolic volume index compared to INOCA (71.7 vs 66.5 mL/m2, p=0.035), suggesting an early HFpEF-like remodeling phenotype.
Cohort (n=177)
Does seismocardiography correlate with echocardiography for cardiac cycle timing markers, and are there structural differences between ANOCA and INOCA?
Seismocardiography strongly correlates with echocardiography for cardiac cycle timing, and ANOCA patients exhibit an early HFpEF-like remodeling phenotype compared to INOCA.
Absolute Event Rate: 71.7% vs 66.5%
p-value: p=0.035
Background: Among patients with no evidence of obstructive coronary artery disease (NOCAD), a subset has evidence of ischemia on prior stress testing.However, it remains unknown if there are structural differences between NOCAD with ischemia (INOCA) and those without ischemia (ANOCA).Methods: In a prospective registry-based cohort of NOCAD patients (<50% stenosis), who had undergone invasive coronary function testing for coronary microvascular dysfunction (CMD) assessment and cardiac MRI, we compared differences in ANOCA and INOCA (evidence of stress induced ischemia on prior stress test) patients.Results: Among 177 patients (96 ANOCA, 81 INOCA), ANOCA patients reported more severe angina (SAQ-7: 38.5 vs 45.8, p=0.018).As compared to ANOCA, INOCA patients demonstrated lower LV enddiastolic volume index (71.7 vs 66.5 mL/m 2 , p=0.035), LV end-systolic volume index (31.1 vs 28.6 mL/m 2 , p=0.044), and cardiac output (5.2 vs 4.8 L/min, p=0.025), with preserved ejection fraction in both groups.In contrast, INOCA patients exhibited higher global native T1 values (1038 vs 1027 ms, p=0.012), consistent with ischemia-related myocardial tissue changes.Conclusions: ANOCA is associated with increased left ventricular volumes and higher cardiac output despite preserved ejection fraction in both ANOCA and INOCA groups, suggesting an early heart failure with preserved ejection fraction (HFpEF) like remodeling phenotype distinct from INOCA that warrants further investigation.
Singh et al. (Wed,) conducted a cohort in No evidence of obstructive coronary artery disease (NOCAD) (n=177). ANOCA (NOCAD without ischemia) vs. INOCA (NOCAD with ischemia) was evaluated on Left ventricular end-diastolic volume index (p=0.035). ANOCA was associated with higher left ventricular end-diastolic volume index compared to INOCA (71.7 vs 66.5 mL/m2, p=0.035), suggesting an early HFpEF-like remodeling phenotype.