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This research explores how non-linear effects impact adsorption events in chromatography.

May 6, 2026The Analyst0 citations

The non-linear effects of the number of stochastic single-molecule adsorption events on ensemble elution profiles

RNRicardo Monge NeriaCase Western Reserve University RSRachel A. SaylorOberlin College LKLydia KisleyCase Western Reserve University

Key Points

This research explores how non-linear effects impact adsorption events in chromatography.
Utilized stochastic model of chromatography to analyze adsorption events.
Employed single-molecule microscopy for visualization of molecular analytes.
Examined elution profiles based on varying numbers of adsorption events.
Identified significant non-linear effects on ensemble elution profiles.
Demonstrated the impact of single-molecule events on molecular mass transfer.
Highlighted potential optimizations for chromatographic separation techniques.

Abstract

The stochastic model of chromatography mathematically represents the molecular mass transfer that occurs during a separation. Single-molecule microscopy allows for direct visualization of molecular analytes adsorbing within column materials. Experimental...

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