The non-linear effects of the number of stochastic single-molecule adsorption events on ensemble elution profiles

Ricardo Monge Neria; Rachel A. Saylor; Lydia Kisley

doi:10.1039/d6an00199h

January 1, 2026The Analyst

The non-linear effects of the number of stochastic single-molecule adsorption events on ensemble elution profiles

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Key Points

This research explores how non-linear effects impact adsorption events in chromatography.
Utilized stochastic model of chromatography to analyze adsorption events.
Employed single-molecule microscopy for visualization of molecular analytes.
Examined elution profiles based on varying numbers of adsorption events.
Identified significant non-linear effects on ensemble elution profiles.
Demonstrated the impact of single-molecule events on molecular mass transfer.
Highlighted potential optimizations for chromatographic separation techniques.

Implication

Stochastic model reveals non-linear adsorption impacts on molecular separation in chromatography, suggesting enhanced understanding for optimizing methods.

Abstract

The stochastic model of chromatography mathematically represents the molecular mass transfer that occurs during a separation. Single-molecule microscopy allows for direct visualization of molecular analytes adsorbing within column materials. Experimental...

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Cite This Study

Neria et al. (2026) studied this question.

synapsesocial.com/papers/69fa8eca04f884e66b531277 https://doi.org/10.1039/d6an00199h

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The non-linear effects of the number of stochastic single-molecule adsorption events on ensemble elution profiles

Key Points

Implication

Abstract

Discussion

Cite This Study

The non-linear effects of the number of stochastic single-molecule adsorption events on ensemble elution profiles

Key Points

Implication

Abstract

Discussion

Cite This Study

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