Structure-Activity Relationship Studies for 1,3,4-Thiadiazole-Based Bacterial Carbonic Anhydrase Inhibitors with In Vivo Efficacy against Drug-Resistant Neisseria gonorrhoeae

Key Points

• The research aims to explore the efficacy of thiadiazole-based inhibitors targeting bacterial carbonic anhydrase to combat drug-resistant Neisseria gonorrhoeae.
• Conducted structure-activity relationship studies to identify effective compounds.
• Evaluated in vivo efficacy against Neisseria gonorrhoeae.
• Analyzed the potential of the compounds as new therapeutics.
• Identified several thiadiazole compounds with significant inhibitory activity against carbonic anhydrase.
• Demonstrated in vivo efficacy against drug-resistant Neisseria gonorrhoeae in tested models.
• Indicated potential for development of new therapeutic options.