Structure-Activity Relationship Studies for 1,3,4-Thiadiazole-Based Bacterial Carbonic Anhydrase Inhibitors with In Vivo Efficacy against Drug-Resistant Neisseria gonorrhoeae

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The research aims to explore the efficacy of thiadiazole-based inhibitors targeting bacterial carbonic anhydrase to combat drug-resistant Neisseria gonorrhoeae.
Conducted structure-activity relationship studies to identify effective compounds.
Evaluated in vivo efficacy against Neisseria gonorrhoeae.
Analyzed the potential of the compounds as new therapeutics.
Identified several thiadiazole compounds with significant inhibitory activity against carbonic anhydrase.
Demonstrated in vivo efficacy against drug-resistant Neisseria gonorrhoeae in tested models.
Indicated potential for development of new therapeutic options.

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Explores in vivo efficacy of thiadiazole compounds against drug-resistant Neisseria gonorrhoeae, suggesting new therapeutic options.

and may be an answer in the search for new therapeutics.

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Tharra et al. (2026) studied this question.

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