Hyaluronic acid/kaempferol-functionalized Fe₃O₄ nanoparticles promote ROS-associated apoptosis and modulate caspase-8/BCRT1 axis in triple-negative breast cancer

Key Points

• To investigate the effects of hyaluronic acid/kaempferol-functionalized Fe₃O₄ nanoparticles on apoptosis in triple-negative breast cancer cells.
• Utilized functionalized Fe₃O₄ nanoparticles designed to target TNBC cells.
• Analyzed the modulation of apoptosis markers and signaling pathways, including caspase-8 and BCRT1.
• Demonstrated significant apoptosis induction via reactive oxygen species (ROS) signaling.
• Notable modulation of caspase-8/BCRT1 axis was observed in treated TNBC cells.