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May 12, 2026Scientific ReportsOpen Access

Hyaluronic acid/kaempferol-functionalized Fe₃O₄ nanoparticles promote ROS-associated apoptosis and modulate caspase-8/BCRT1 axis in triple-negative breast cancer

Deniz kazemzadeh Ali Salehzadeh S. Shariati Seyed Ataollah Sadat Shandiz

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Key Points

To investigate the effects of hyaluronic acid/kaempferol-functionalized Fe₃O₄ nanoparticles on apoptosis in triple-negative breast cancer cells.
Utilized functionalized Fe₃O₄ nanoparticles designed to target TNBC cells.
Analyzed the modulation of apoptosis markers and signaling pathways, including caspase-8 and BCRT1.
Demonstrated significant apoptosis induction via reactive oxygen species (ROS) signaling.
Notable modulation of caspase-8/BCRT1 axis was observed in treated TNBC cells.

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Implication

Demonstrates enhanced apoptosis in triple-negative breast cancer, suggesting a novel treatment strategy.

Abstract

@Glu-HA-KAE NPs against TNBC cells, representing an innovative approach to combat TNBC.

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Cite This Study

kazemzadeh et al. (2026) studied this question.

synapsesocial.com/papers/6a06b7a1e7dec685947aa677 https://doi.org/10.1038/s41598-026-50528-9

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