IFE-based lysosome-targeted probe for different response behaviors to biothiols and bioimaging

Key Points

• This research aims to explore the interactions between biothiols and a lysosome-targeted probe for bioimaging applications.
• Developed an IFE-based probe targeting lysosomes.
• Evaluated response behaviors of cysteine, homocysteine, and glutathione in bioimaging context.
• Analyzed the differential roles of biothiols in maintaining lysosomal activity.
• The probe effectively localized in lysosomes, enhancing bioimaging accuracy.
• Different biothiols exhibited distinct response behaviors with the probe, indicating their varied functional roles in lysosomes.