IFE-based lysosome-targeted probe for different response behaviors to biothiols and bioimaging

Yuan Xu; Yujia Hou; Tongtong Zhao; Huilin Chen; Hanxi Chai; Zhengrui Zhang; Zhuoyan Cao; Kai‐Xin Xie; Qiaoling Liu

doi:10.1039/d6an00211k

January 1, 2026The Analyst

IFE-based lysosome-targeted probe for different response behaviors to biothiols and bioimaging

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Key Points

This research aims to explore the interactions between biothiols and a lysosome-targeted probe for bioimaging applications.
Developed an IFE-based probe targeting lysosomes.
Evaluated response behaviors of cysteine, homocysteine, and glutathione in bioimaging context.
Analyzed the differential roles of biothiols in maintaining lysosomal activity.
The probe effectively localized in lysosomes, enhancing bioimaging accuracy.
Different biothiols exhibited distinct response behaviors with the probe, indicating their varied functional roles in lysosomes.

Implication

Investigates lysosome-targeted probe responses to biothiols, suggesting new bioimaging techniques.

Abstract

Biothiols (Cys, Hcy, and GSH) are generated by reducing disulphide bonds with the help of proteolysis in lysosomes, meanwhile three biothiols play the different roles in preserving the optimal activity...

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a06b8a7e7dec685947ab16f https://doi.org/10.1039/d6an00211k

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IFE-based lysosome-targeted probe for different response behaviors to biothiols and bioimaging

Key Points

Implication

Abstract

Discussion

Cite This Study

IFE-based lysosome-targeted probe for different response behaviors to biothiols and bioimaging

Key Points

Implication

Abstract

Discussion

Cite This Study

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