A Novel Coumarin/Quinolinium-Based Fluorescent Probe for the Detection and Bioimaging of Intracellular Biothiols

Dong-Shuai Shang; Mingzhu Shao; Sheng-Shuo Xiao; Yunbo Wei; Xin-Yu Zhou; Ya-Nan Jin; Li-Ya Xin; Yu Liu; Zhong-Long Zhou; Changsheng Xu; Cheng‐Shi Jiang; Ning Meng; Kai-Ming Wang

doi:10.1039/d6nj00211k

January 1, 2026New Journal of Chemistry

A Novel Coumarin/Quinolinium-Based Fluorescent Probe for the Detection and Bioimaging of Intracellular Biothiols

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Key Points

The aim is to develop a new fluorescent probe to detect and image intracellular biothiols.
Development of a coumarin/quinolinium-based fluorescent probe
Testing the probe's ability to detect cysteine, homocysteine, and glutathione in cells
Evaluation of probe's effectiveness through bioimaging techniques
The probe successfully detects key biothiols within living cells
Demonstrated potential for imaging cellular redox states
Indicated significant differences in biothiol levels in pathological versus healthy conditions

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Implication

Novel probe detects biothiols in cells, highlighting their role in health and disease.

Abstract

Biothiols, including cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), are crucial redox regulators whose dysfunction is implicated in numerous pathological conditions. Herein, we present a coumarin/quinolinium-based probe, SDS-Bio, which could...

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Shang et al. (2026) studied this question.

synapsesocial.com/papers/69c6204c15a0a509bde18b51 https://doi.org/10.1039/d6nj00211k

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A Novel Coumarin/Quinolinium-Based Fluorescent Probe for the Detection and Bioimaging of Intracellular Biothiols

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A Novel Coumarin/Quinolinium-Based Fluorescent Probe for the Detection and Bioimaging of Intracellular Biothiols

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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