Stabilization of the ring-opened Rhodamine probe via multinoncovalent interactions for dual-mode detection of nitazenes

Key Points

• This study aims to develop a stabilized rhodamine probe for the dual-mode detection of nitazenes, a class of synthetic opioids.
• Utilized multinoncovalent interactions for stabilizing the ring-opened rhodamine probe.
• Conducted tests to assess detection sensitivity for nitazenes in various conditions.
• Analyzed performance through comparative studies with conventional detection methods.
• The stabilized rhodamine probe showed a 75% increase in detection sensitivity for nitazenes (p<0.01).
• Dual-mode detection enabled rapid identification of nitazenes under different environmental conditions, improving response times.
• Potential applications in public health monitoring and drug safety programs were underscored.