Perivascular adipose tissue secretes both pro-inflammatory and anti-inflammatory adipokines that play a multifaceted role in regulating vascular homeostasis and cardiovascular disease progression.
Perivascular adipose tissue and the vessel wall are connected through intricate bidirectional paracrine and vascular secretory signaling pathways. The secretion of inflammatory factors and oxidative products by the vessel wall in the diseased segment has the ability to influence the phenotype of perivascular adipocytes. Additionally, the secretion of adipokines by perivascular adipose tissue exacerbates the inflammatory response in the diseased vessel wall. Therefore, quantitative and qualitative studies of perivascular adipose tissue are of great value in the context of vascular inflammation and may provide a reference for the assessment of cardiovascular ischemic disease.
Cai et al. (Tue,) conducted a review in Cardiovascular disease. Perivascular adipose tissue secretes both pro-inflammatory and anti-inflammatory adipokines that play a multifaceted role in regulating vascular homeostasis and cardiovascular disease progression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: