Key result
Perivascular adipose tissue regulates vascular homeostasis and CVD progression via pro-inflammatory and anti-inflammatory adipokines.
Why the study?
Understanding perivascular adipose tissue and vessel wall signaling is of value in vascular inflammation and may aid cardiovascular ischemic disease assessment.
Perivascular adipose tissue acts as a crucial endocrine organ whose secreted adipokines play a complex, bidirectional role in vascular homeostasis and the pathogenesis of cardiovascular disease.
Does not yet inform clinical CVD decisions; leaves open targeted PVAT adipokine trials.
Perivascular adipose tissue and the vessel wall are connected through intricate bidirectional paracrine and vascular secretory signaling pathways. The secretion of inflammatory factors and oxidative products by the vessel wall in the diseased segment has the ability to influence the phenotype of perivascular adipocytes. Additionally, the secretion of adipokines by perivascular adipose tissue exacerbates the inflammatory response in the diseased vessel wall. Therefore, quantitative and qualitative studies of perivascular adipose tissue are of great value in the context of vascular inflammation and may provide a reference for the assessment of cardiovascular ischemic disease.
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Cai et al. (2023) conducted a review in Cardiovascular disease. Perivascular adipose tissue secretes both pro-inflammatory and anti-inflammatory adipokines that play a multifaceted role in regulating vascular homeostasis and cardiovascular disease progression.
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