A computational model predicts that a stand test in Mars gravity after prolonged space flight will not induce significant orthostatic intolerance, maintaining mean arterial pressure with only a 10% drop in cardiac output.
Does a computational model predict adequate hemodynamic response to an active stand test on Mars after prolonged spaceflight?
A computational model of the cardiopulmonary system suggests that astronauts will be able to maintain adequate blood pressure during orthostatic stress upon arriving on Mars after prolonged spaceflight, even without fluid loading.
Astronauts in a microgravity environment will experience significant changes in their cardiopulmonary system. Up until now, there has always been the reassurance that they have real-time contact with experts on Earth. Mars crew however will have gaps in their communication of 20 min or more. In silico experiments are therefore needed to assess fitness to fly for those on future space flights to Mars. In this study, we present an open-source controlled lumped mathematical model of the cardiopulmonary system that is able simulate the short-term adaptations of key hemodynamic parameters to an active stand test after being exposed to microgravity. The presented model is capable of adequately simulating key cardiovascular hemodynamic changes-over a short time frame-during a stand test after prolonged spaceflight under different gravitational conditions and fluid loading conditions. This model can form the basis for further exploration of the ability of the human cardiovascular system to withstand long-duration space flight and life on Mars.
Loon et al. (Tue,) conducted a other in Orthostatic intolerance. Stand test in Mars gravity after prolonged space flight vs. Stand test in Earth gravity was evaluated on Mean arterial pressure and cardiac output during stand test. A computational model predicts that a stand test in Mars gravity after prolonged space flight will not induce significant orthostatic intolerance, maintaining mean arterial pressure with only a 10% drop in cardiac output.