ACE and AT1R gene polymorphisms were not associated with left ventricular mass, but the AT1R CC mutation was linked to a lower ejection fraction compared to allele A (62% vs 68%, P<0.05).
Observational (n=141)
No
Do ACE and AT1R gene polymorphisms affect left ventricular function and mass in patients with angiographically normal coronary arteries?
ACE and AT1R gene polymorphisms are not associated with left ventricular hypertrophy in white patients with normal coronary arteries, though the AT1R CC mutation may be associated with a slightly lower ejection fraction.
Absolute Event Rate: 62% vs 68%
p-value: p=< 0.05
OBJECTIVE: To analyse the potential association of the angiotensin converting enzyme (ACE) and angiotensin II type 1 receptor (AT1R) gene polymorphisms on left ventricular function and mass in patients with normal coronary arteries. DESIGN: Consecutive sample. SETTING: University hospital. SUBJECTS: 141 consecutive white patients referred for coronary angiography and with angiographically normal coronary arteries. Patients with valvar diseases, cardiomyopathies, or a history of myocardial infarction were excluded. MAIN OUTCOME MEASURES: Left ventricular variables were measured for all patients. The ACE and AT1R genotypes were determined with a polymerase chain reaction based protocol using DNA prepared from white blood cells. A general linear model was used to compare data according to the ACE and to the AT1R genotypes. RESULTS: A strong association was observed between left ventricular mass and systemic hypertension (mean (SD) hypertension: 114 (31) g/m2; no hypertension 98 (23) g/m2; P < 0.003). However, no influence of ACE and AT1R polymorphisms on left ventricular mass was found, regardless of systemic hypertension. The subjects homozygous for the AT1R CC mutation had a significantly lower ejection fraction than those with allele A (AC+AA) (mean (SD) 62(12)% and 68(10)%, respectively, P < 0.05). No synergistic interaction of ACE and AT1R gene polymorphisms on left ventricular function and mass was found. CONCLUSIONS: These data do not support an association of the ACE and AT1R genotypes on left ventricular hypertrophy in white patients with normal coronary arteries.
Hamon et al. (Sun,) conducted a observational in Angiographically normal coronary arteries (n=141). ACE and AT1R gene polymorphisms vs. Alternative genotypes was evaluated on Left ventricular function and mass (p=< 0.05). ACE and AT1R gene polymorphisms were not associated with left ventricular mass, but the AT1R CC mutation was linked to a lower ejection fraction compared to allele A (62% vs 68%, P<0.05).