Key result
ACE and AT1R gene polymorphisms were not associated with left ventricular mass, but the AT1R CC mutation was linked to a lower ejection fraction compared to allele A (62% vs 68%, P<0.05).
Why the study?
Do ACE and AT1R gene polymorphisms affect left ventricular function and mass in patients with angiographically normal coronary arteries?
Observational (n=141)
No
Do ACE and AT1R gene polymorphisms affect left ventricular function and mass in patients with angiographically normal coronary arteries?
Absolute Event Rate: 62% vs 68%
p-value: p=< 0.05
ACE and AT1R gene polymorphisms are not associated with left ventricular hypertrophy in white patients with normal coronary arteries, though the AT1R CC mutation may be associated with a slightly lower ejection fraction.
No takes yet. Share an insight, caveat, or question.
Should not yet change practice or prompt genetic testing; leaves open a possible AT1R CC link to modestly lower EF for prospective study.
Hamon et al. (1997) conducted an observational in Angiographically normal coronary arteries (n=141). ACE and AT1R gene polymorphisms vs. Alternative genotypes was evaluated on Left ventricular function and mass (p=< 0.05). ACE and AT1R gene polymorphisms were not associated with left ventricular mass, but the AT1R CC mutation was linked to a lower ejection fraction compared to allele A (62% vs 68%, P<0.05).
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