What does this research mean for the field?

Dead bag syndrome can manifest as an early-onset complication within 17 months following cataract surgery, characterized by extensive depletion of lens epithelial cells and capsular bag delamination. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to describe the clinical course and histopathological features of dead bag syndrome following cataract surgery.

May 29, 2026Open Access

Early-onset dead bag syndrome following cataract surgery: a case report with clinical and histopathological findings

Key Points

This study aims to describe the clinical course and histopathological features of dead bag syndrome following cataract surgery.
A 55-year-old man with blurred vision 17 months post-cataract surgery was examined.
Histopathological analysis assessed lens epithelial cells and capsular bag integrity.
Patient underwent surgical intervention for intraocular lens dislocation.
Progressive blurry vision linked to dead bag syndrome with partial dislocation of the IOL-capsular bag complex.
Histopathological findings included extensive depletion of lens epithelial cells and reduced fibronectin expression.
Post-surgical intervention led to substantial visual recovery.

Abstract

BACKGROUND: In the present study, we aimed to comprehensively describe the full clinical course of dead bag syndrome (DBS) presenting 17 months after cataract surgery, and to elucidate its clinical characteristics, histopathological features. CASE PRESENTATION: A 55-year-old man presented with progressive blurred vision in his left eye 17 months following an uncomplicated cataract extraction. Ophthalmic examination revealed a lax, translucent capsular bag accompanied by partial dislocation of the intraocular lens (IOL)-capsular bag complex. Histopathological analysis showed extensive depletion of lens epithelial cells (LECs), multilayer delamination of the capsular bag, and markedly reduced fibronectin expression. The patient subsequently underwent removal of the displaced IOL and scleral-sutured implantation of a new IOL, which led to substantial postoperative visual recovery. CONCLUSION: This case indicated that DBS could manifest within a relatively short postoperative interval. Histopathological analysis showed structural alterations of the capsular bag consistent with DBS following cataract surgery. Accordingly, DBS should be recognized as a potential complication and carefully considered during routine postoperative surveillance following cataract surgery.

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