Alzheimer's disease neuropathology plasma biomarkers and cognition in midlife: a community-based cohort study

Key Points

• The aim is to investigate the relationship between plasma biomarkers of Alzheimer's disease neuropathology and cognitive performance in midlife individuals.
• Community-based cohort design with midlife participants
• Assessment of plasma biomarkers related to Alzheimer's disease neuropathology
• Cognitive performance evaluated using standardized tests
• Significant association between elevated plasma biomarkers and cognitive decline observed in midlife participants
• Findings indicate that higher levels of certain biomarkers correlate with lower cognitive scores
• Cognition impairment linked to specific Alzheimer's-related neuropathologies as indicated by biomarkers