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May 1, 2026The Lancet

Alzheimer's disease neuropathology plasma biomarkers and cognition in midlife: a community-based cohort study

Xiaqing Jiang Tina Hoang Leslie M Shaw David R Jacobs Ilya M. Nasrallah R Nick Bryan Kristine Yaffe

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Key Points

The aim is to investigate the relationship between plasma biomarkers of Alzheimer's disease neuropathology and cognitive performance in midlife individuals.
Community-based cohort design with midlife participants
Assessment of plasma biomarkers related to Alzheimer's disease neuropathology
Cognitive performance evaluated using standardized tests
Significant association between elevated plasma biomarkers and cognitive decline observed in midlife participants
Findings indicate that higher levels of certain biomarkers correlate with lower cognitive scores
Cognition impairment linked to specific Alzheimer's-related neuropathologies as indicated by biomarkers

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Implication

Community-based cohort study examines plasma biomarkers and cognition in midlife, suggesting important links.

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Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6a19ae77e2fc26910d02b6f7 https://doi.org/10.1016/s0140-6736(26)00515-5

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