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August 18, 2010JAIDS Journal of Acquired Immune Deficiency SyndromesOpen Access

Increased Coronary Artery Calcium Score and Noncalcified Plaque Among HIV-Infected Men: Relationship to Metabolic Syndrome and Cardiac Risk Parameters

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Why the study?

Does HIV infection with or without metabolic syndrome increase coronary artery calcium score and noncalcified plaque in men?

Population

154 men, comprising HIV-infected men with metabolic syndrome, HIV-infected men without regard to metabolic…

Comparison

HIV infection with metabolic syndrome or HIV… vs HIV-negative controls

Design

Cross-sectional

Authors

KFKathleen V. FitchJLJanet LoSASuhny Abbara

Discussion

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Overview

HIV with or without MS may increase coronary plaque burden; hypothesis-generating and requires prospective validation before changing practice.

Structured PICO

Does HIV infection with or without metabolic syndrome increase coronary artery calcium score and noncalcified plaque in men?

P
Population
154 men, comprising HIV-infected men with metabolic syndrome (n=27), HIV-infected men without regard to metabolic criteria (n=87), and HIV-negative controls (n=40).
I
Intervention
HIV infection with metabolic syndrome (HIV+MS) or HIV infection alone
C
Comparator
HIV-negative controls
O
Outcome
Coronary artery calcium (CAC) score and presence of plaque (including noncalcified plaque) measured by computed tomography coronary angiographysurrogate

Metabolic syndrome in HIV patients is associated with increased coronary calcification, while HIV infection itself is associated with the development of noncalcified coronary lesions.

Cite This Study

Fitch et al. (2010) studied this question.

synapsesocial.com/papers/6a1a68da49c6765e38856b34https://doi.org/10.1097/qai.0b013e3181edab0b
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<scp>HIV</scp> infection is associated with an increased prevalence of coronary noncalcified plaque among participants with a coronary artery calcium score of zero: <scp>M</scp>ulticenter <scp>AIDS C</scp>ohort <scp>S</scp>tudy (<scp>MACS</scp>)2015 · 37 citations
  2. 2Increased prevalence of subclinical coronary atherosclerosis detected by coronary computed tomography angiography in HIV-infected men2009 · 322 citations
  3. 3Incidence and progression of coronary artery calcium in HIV-infected and HIV-uninfected men2015 · 17 citations
  4. 4Subclinical coronary artery disease in Swiss HIV-positive and HIV-negative persons2018 · 65 citations
  5. 5Coronary atherosclerosis characteristics in HIV-infected patients on long-term antiretroviral therapy2019 · 25 citations