Why the study?
Does HIV infection increase the prevalence and severity of subclinical coronary atherosclerosis compared to HIV-negative controls?
Population
428 HIV-positive participants of the Swiss HIV Cohort Study and 276 HIV-negative controls concurrently…
Comparison
HIV-positive status vs HIV-negative controls
Design
Cross-sectional
Key result
HIV-positive individuals had a lower prevalence of calcified coronary plaque compared to HIV-negative controls (36.9% vs. 48.6%; aOR 0.57; 95% CI 0.40-0.82; P<0.01).
Authors
Loading...
Similar plaque burden in well-treated HIV+ versus matched controls; leaves open whether higher event rates reflect non-plaque mechanisms.
Cross-Sectional (n=704)
Yes
Does HIV infection increase the prevalence and severity of subclinical coronary atherosclerosis compared to HIV-negative controls?
Odds Ratio: 0.57 (95% CI 0.4–0.82)
Absolute Event Rate: 36.9% vs 48.6%
p-value: p=<0.01
HIV-positive persons had similar non-calcified/mixed plaque but less calcified plaque and lower atherosclerosis severity scores compared to HIV-negative persons with similar Framingham risk scores.
Tarr et al. (2018) conducted a cross-sectional in Subclinical coronary artery disease in HIV (n=704). HIV infection vs. HIV-negative controls was evaluated on Prevalence of calcified plaque (aOR 0.57, 95% CI 0.40-0.82, p=<0.01). HIV-positive individuals had a lower prevalence of calcified coronary plaque compared to HIV-negative controls (36.9% vs. 48.6%; aOR 0.57; 95% CI 0.40-0.82; P<0.01).