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April 1, 1987The Journal of ImmunologyOpen Access

Susceptible A.CA and A.SW mice produced cardiac myosin-specific IgG autoantibodies, whereas non-susceptible B10.PL/SgSf and B10.A/SgSf mice produced only IgM autoantibodies cross-reactive with all three myosin isoforms.

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Why the study?

Are specific autoantibodies associated with susceptibility to Coxsackievirus B3-induced myocarditis in mice?

Population

Mouse strains susceptible and non-susceptible to immunopathic myocarditis after infection with…

Comparison

Infection with Coxsackievirus B3 (CB3) vs Comparison between susceptible and…

Design

Preclinical

Authors

NNNikolaus NeuKBKirk W. BeiselMTMonica D. Traystman

Discussion

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Overview

IgG cardiac myosin autoantibodies may mark autoimmune myocarditis susceptibility in mice; hypothesis-generating for human serologic markers.

Structured PICO

Are specific autoantibodies associated with susceptibility to Coxsackievirus B3-induced myocarditis in mice?

P
Population
Mouse strains susceptible (A.CA and A.SW) and non-susceptible (B10.PL/SgSf and B10.A/SgSf) to immunopathic myocarditis after infection with Coxsackievirus B3
I
Intervention
Infection with Coxsackievirus B3 (CB3)
C
Comparator
Comparison between susceptible and non-susceptible mouse strains
O
Outcome
Reactivity of sera with three different myosin isoforms (heart, skeletal muscle, and brain myosins) and autoantibody isotypesurrogate

Heart-specific myosin autoantibodies (IgG) are found exclusively in mouse strains that develop immunopathic myocarditis after Coxsackievirus B3 infection, serving as a potential serologic marker for autoimmune heart disease.

Cite This Study

Neu et al. (1987) studied this question.

synapsesocial.com/papers/6a1c72c5107ed6dc7cc3d48ahttps://doi.org/10.4049/jimmunol.138.8.2488
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Induction of multiple heart autoantibodies in mice with coxsackievirus B3- and cardiac myosin-induced autoimmune myocarditis.1994 · 97 citations
  2. 2Cardiac Myosin and Autoimmune Myocarditis2007 · 60 citations
  3. 3Experimentally-Induced Autoimmune Myocarditis: Production of Heart Myosin-Specific Autoantibodies Within the Inflammatory Infiltrate1991 · 18 citations
  4. 4Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis.1985 · 149 citations
  5. 5Cardiac myosin-induced myocarditis. Heart autoantibodies are not involved in the induction of the disease.1990 · 102 citations