Why the study?
Does Coxsackievirus B3 infection induce heart-specific autoantibodies in A.SW/SnJ mice?
Does Coxsackievirus B3 infection induce heart-specific autoantibodies in A.SW/SnJ mice?
This study establishes a murine model demonstrating that Coxsackievirus B3 infection induces heart-specific autoantibodies, suggesting an autoimmune component in viral myocarditis pathogenesis.
May implicate autoimmunity in viral myocarditis; leaves open translation to human disease and therapy.
The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart-reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.
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Wolfgram et al. (1985) studied this question.
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