Why the study?
Does Coxsackievirus B3 infection induce elutable heart-specific IgG autoantibodies in susceptible mice?
Population
Susceptible (A/J) and resistant (B10.A) mice
Comparison
Coxsackievirus B3 infection vs Control treatment
Design
Preclinical
Authors
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Supports myosin-specific autoimmunity in susceptible murine CVB3 myocarditis; leaves open translation to human viral myocarditis.
Does Coxsackievirus B3 infection induce elutable heart-specific IgG autoantibodies in susceptible mice?
In vivo IgG deposition occurs in the hearts of susceptible mice with Coxsackievirus B3-induced autoimmune myocarditis, with specificity similar to serum autoantibodies.
Neumann et al. (1991) studied this question.
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