What is the clinical evidence from this study?

Study design: Other. Population: acute myocarditis. Intervention: anti-CVB3m-neutralizing monoclonal antibodies. Primary outcome: induction of focal myocarditic lesions.

What does this research mean for the field?

Certain anti-coxsackievirus B3 neutralizing antibodies can cross-react with normal cardiac tissue epitopes and directly induce focal myocarditic lesions in mice. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 2, 1991European Heart Journal

Anti-coxsackievirus B3 neutralizing antibodies with pathological potential

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Key result

Anti-CVB3m-neutralizing monoclonal antibody induces virus-like focal myocarditic lesions in adolescent mice.

Population

Adolescent CD-1 mice inoculated with coxsackievirus B3 and cultured murine cardiac or neonatal skin…

Design

Preclinical

Follow-up

7 days post-inoculation

Authors

CGCharles J. GaunttThe University of Texas Health Science Center at San Antonio HAH. M. ArizpeHyperion Technologies (Canada)AHArlene L. HigdonThe University of Texas Health Science Center at San Antonio

Discussion

Member takes

Implication

May signal cardiac risk from anti-CVB3 mAbs; leaves open relevance to human myocarditis.

Structured PICO

Population

Adolescent CD-1 mice inoculated with coxsackievirus B3 to study the pro-inflammatory properties of virus-induced antibodies.

Intervention

Administration of murine sera containing anti-CVB3m-neutralizing antibodies or anti-CVB3m-neutralizing monoclonal antibodies (mAbs) (e.g., three doses of ~5 micrograms)

Outcome

Development of focal myocarditic lesions and in vitro binding/lysis of fibroblastssurrogate

Anti-coxsackievirus B3 neutralizing antibodies may exacerbate myocarditis by cross-reacting with normal heart tissues and stimulating proinflammatory reactions.

Cite This Study

Gauntt et al. (1991) studied acute myocarditis. anti-CVB3m-neutralizing monoclonal antibodies was evaluated on induction of focal myocarditic lesions. Injection of one anti-CVB3m-neutralizing monoclonal antibody (3 doses of ~5 micrograms) into adolescent mice induced focal myocarditic lesions similar to virus-induced lesions.

synapsesocial.com/papers/6aa913b169e4513914299bee https://doi.org/10.1093/eurheartj/12.suppl_d.124

Topics

Myocarditis

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Anti-coxsackievirus B3 neutralizing antibodies with pathological potential

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Anti-coxsackievirus B3 neutralizing antibodies with pathological potential

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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