Population
Adolescent CD-1 mice and HeLa cells
Comparison
Inoculation with coxsackievirus B3 variant CVB3m vs Inoculation with coxsackievirus B3 variant CVB3o
Design
Preclinical
Authors
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Animal data support dual viral-immune pathogenesis in CVB3 myocarditis; extends mechanism but leaves open human translation and should not change practice.
Induction of myocarditis by CVB3 requires both viral destruction of myocytes and subsequent cell-mediated immune responses to new antigens.
Gauntt et al. (1979) studied this question.
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