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March 1, 1995The Journal of Immunology

Molecular mimicry, anti-coxsackievirus B3 neutralizing monoclonal antibodies, and myocarditis.

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Population

Normal adolescent male CD-1 or C3H/HeJ mice and cultured murine cardiac fibroblasts

Design

Preclinical

Authors

CGCharles J. GaunttThe University of Texas Health Science Center at San AntonioHAH. M. ArizpeHyperion Technologies (Canada)AHArlene L. HigdonThe University of Texas Health Science Center at San Antonio

Discussion

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Implication

Raises caution for antibody therapies targeting CVB3; leaves open whether molecular mimicry sustains chronic human myocarditis.

Structured PICO

P
Population
Normal adolescent male CD-1 or C3H/HeJ mice and cultured murine cardiac fibroblasts
I
Intervention
Anti-coxsackievirus B3 (CVB3) neutralizing monoclonal antibodies (mAbs) administered via i.p. inoculation or applied in vitro
O
Outcome
Cardiopathologic alterations in vivo and proinflammatory reactions in vitrosurrogate

The study provides preclinical evidence that molecular mimicry via anti-CVB3 neutralizing antibodies can sustain chronic inflammation in myocarditis.

Cite This Study

Gauntt et al. (1995) studied this question.

synapsesocial.com/papers/6a709f26e71d69abee08bc3bhttps://doi.org/10.4049/jimmunol.154.6.2983

Topics

Myocarditis
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-coxsackievirus B3 neutralizing antibodies with pathological potential1991 · 40 citations
  2. 2Coxsackievirus-B3-induced myocarditis: virus receptor antibodies modulate myocarditis.1989 · 53 citations
  3. 3Coxsackievirus-induced chronic myocarditis in murine models1995 · 35 citations
  4. 4Properties of coxsackievirus B3 variants which are amyocarditic or myocarditic for mice1979 · 138 citations
  5. 5Experimental CVB3-induced chronic myocarditis in two murine strains: Evidence of interrelationships between virus replication and myocardial damage in persistent cardiac infection1997 · 60 citations