Key result
Co-administration of CVB3 with anti-CVB2 antibody in mice resulted in viral titres 1-2 logs higher than CVB3 alone, accompanied by greater histopathological damage in the heart.
Why the study?
Does anti-CVB2 antibody enhance CVB3 infection and myocardial damage in murine models?
Population
Murine macrophage cell line J774.1 (in vitro) and 5-week-old mice (in vivo)
Comparison
Coxsackievirus B3 plus mouse polyclonal… vs PBS or CVB3 alone
Design
Preclinical
Authors
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Antibody enhancement may worsen CVB3 cardiac injury in mice; leaves open relevance to human myocarditis.
Does anti-CVB2 antibody enhance CVB3 infection and myocardial damage in murine models?
Antibody enhancement of infectivity by cross-reactive antibodies may exacerbate coxsackievirus pathogenesis and myocardial damage.
Girn et al. (2002) studied Coxsackievirus B3 infection. CVB3 plus anti-CVB2 antibody vs. PBS or CVB3 alone was evaluated on Viral yield/titres and histopathological damage. Co-administration of CVB3 with anti-CVB2 antibody in mice resulted in viral titres 1-2 logs higher than CVB3 alone, accompanied by greater histopathological damage in the heart.
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