January 1, 2000Journal of Medical VirologyOpen Access

Group B coxsackievirus myocarditis and pancreatitis: Connection between viral virulence phenotypes in mice

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Structured PICO

Population

Mice, human pancreatic tumor lines, and primary human endothelial cell cultures derived from cardiac artery

Intervention

Inoculation with different strains of group B coxsackieviruses (CVB), including 9 genotypically different type 3 CVB (CVB3) strains

Comparator

Comparison between different CVB strains (avirulent, pancreovirulent only, and cardiovirulent)

Outcome

Development of acute pancreatitis and acute myocarditis, and infectious virus titers in serum, pancreas, and heartsurrogate

Preclinical data suggest an etiologic link between CVB-induced pancreatitis and myocarditis, with cardiovirulent strains showing higher replication and persistence.

Discussion

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Implication

Hypothesis-generating for CVB3 linking pancreatitis and myocarditis; clinical relevance in humans remains to be determined.

Cite This Study

Tracy et al. (2000) studied this question.

synapsesocial.com/papers/69c9f0ef72920516e45dbde5 https://doi.org/10.1002/1096-9071(200009)62:1<70::aid-jmv11>3.0.co;2-r

Topics

Myocarditis

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Group B coxsackievirus myocarditis and pancreatitis: Connection between viral virulence phenotypes in mice

Structured PICO

Discussion

Implication

Cite This Study

Topics

Group B coxsackievirus myocarditis and pancreatitis: Connection between viral virulence phenotypes in mice

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider