High lipoprotein (a) concentrations (≥50 mg/dL) were not associated with higher ADP-induced platelet reactivity compared to lower concentrations in individuals with or without coronary artery disease.
Cross-Sectional (n=396)
No
Does high Lp(a) concentration increase platelet reactivity in individuals with and without CAD?
High Lp(a) concentrations (≥ 50 mg/dL) are not associated with increased platelet reactivity in stable individuals with or without coronary artery disease.
Effect estimate: OR 1.00 (95% CI 0.99-1.01)
Absolute Event Rate: 249.4% vs 243.1%
p-value: p=0.590
INTRODUCTION: Lipoprotein (a) Lp(a) is a risk factor for coronary artery disease (CAD). To the best of our knowledge, this is the first study addressing the relationship between Lp(a) and platelet reactivity in primary and secondary prevention. METHODS: assay. Platelet reactivity was also induced by arachidonic acid and collagen-epinephrine (C-EPI) and assessed by Multiplate™, platelet function analyzer™ 100 (PFA-100), and light transmission aggregometry (LTA) assays. Secondary objectives included the assessment of the primary endpoint in individuals with or without CAD. RESULTS: Overall, 294 (74.2%) individuals had Lp(a) 0.05). Finally, multivariable analysis did not show a significant association between ADP-induced platelet reactivity and Lp(a) ≥ 50 mg/dL adjusted OR = 1.00 [(95% CI 0.99-1.01), P = 0.590. CONCLUSION: In individuals with or without CAD, Lp(a) ≥ 50 mg/dL was not associated with higher platelet reactivity.
Salsoso et al. (2020) conducted a cross-sectional in Coronary Artery Disease (n=396). Lipoprotein (a) ≥ 50 mg/dL vs. Lipoprotein (a) < 50 mg/dL was evaluated on ADP-induced platelet reactivity (VerifyNow P2Y12 assay) (OR 1.00, 95% CI 0.99-1.01, p=0.590). High lipoprotein (a) concentrations (≥50 mg/dL) were not associated with higher ADP-induced platelet reactivity compared to lower concentrations in individuals with or without coronary artery disease.