Key result
High lipoprotein (a) concentrations (≥50 mg/dL) were not associated with higher ADP-induced platelet reactivity compared to lower concentrations in individuals with or without coronary artery disease.
Why the study?
Lipoprotein (a) is a risk factor for coronary artery disease, but its relationship with platelet reactivity in primary and secondary prevention had not been addressed.
Does high Lp(a) concentration increase platelet reactivity in individuals with and without CAD?
Cross-Sectional (n=396)
No
Does high Lp(a) concentration increase platelet reactivity in individuals with and without CAD?
Answers are grounded in this paper and cite their sources.
High Lp(a) concentrations (≥ 50 mg/dL) are not associated with increased platelet reactivity in stable individuals with or without coronary artery disease.
INTRODUCTION: Lipoprotein (a) [Lp(a)] is a risk factor for coronary artery disease (CAD). To the best of our knowledge, this is the first study addressing the relationship between Lp(a) and platelet reactivity in primary and secondary prevention. METHODS: assay. Platelet reactivity was also induced by arachidonic acid and collagen-epinephrine (C-EPI) and assessed by Multiplate™, platelet function analyzer™ 100 (PFA-100), and light transmission aggregometry (LTA) assays. Secondary objectives included the assessment of the primary endpoint in individuals with or without CAD. RESULTS: Overall, 294 (74.2%) individuals had Lp(a) < 50 mg/dL [median (IQR) 13.2 (5.8-27.9) mg/dL] and 102 (25.8%) had Lp(a) ≥ 50 mg/dL [82.5 (67.6-114.5) mg/dL], P < 0.001. Univariate analysis in the entire population revealed no differences in ADP-induced platelet reactivity between individuals with Lp(a) ≥ 50 mg/dL (249.4 ± 43.8 PRU) versus Lp(a) < 50 mg/dL (243.1 ± 52.2 PRU), P = 0.277. Similar findings were present in individuals with (P = 0.228) and without (P = 0.669) CAD, and regardless of the agonist used or method of analysis (all P > 0.05). Finally, multivariable analysis did not show a significant association between ADP-induced platelet reactivity and Lp(a) ≥ 50 mg/dL [adjusted OR = 1.00 [(95% CI 0.99-1.01), P = 0.590]. CONCLUSION: In individuals with or without CAD, Lp(a) ≥ 50 mg/dL was not associated with higher platelet reactivity.
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Salsoso et al. (2020) conducted a cross-sectional in Coronary Artery Disease (n=396). Lipoprotein (a) ≥ 50 mg/dL vs. Lipoprotein (a) < 50 mg/dL was evaluated on ADP-induced platelet reactivity (VerifyNow P2Y12 assay) (OR 1.00, 95% CI 0.99-1.01, p=0.590). High lipoprotein (a) concentrations (≥50 mg/dL) were not associated with higher ADP-induced platelet reactivity compared to lower concentrations in individuals with or without coronary artery disease.
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