Does pressure overload via aorta banding increase the production of endothelin-1 in the hypertrophied rat heart?
Endogenous endothelin-1 production is increased in the hypertrophied left ventricle of rats subjected to pressure overload, suggesting its involvement in the development of cardiac hypertrophy.
Endothelin-1 (ET-1) has been demonstrated to induce hypertrophy in cultured cardiac myocytes. We investigated the production of ET-1 in the heart of aorta-banded rats in vivo. Seven days after the banding of the abdominal aorta, rats developed a significant left ventricular hypertrophy. The tissue content of mature ET-1 and the level of expression of prepro ET-1 mRNA were higher in the left ventricle of aorta-banded rats than in those of sham-operated rats. The expression of prepro ET-1 mRNA in the right ventricle was not different between the two groups. These findings indicate that the production of ET-1 increased in the hypertrophied left ventricle, thereby suggesting the possible involvement of endogenous ET-1 in the development of cardiac hypertrophy due to pressure overload.
Yorikane et al. (Mon,) studied this question.
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