Why the study?
Does pressure overload via aorta banding increase the production of endothelin-1 in the hypertrophied rat heart?
Population
Aorta-banded rats (in vivo model of pressure overload-induced left ventricular hypertrophy)
Comparison
Abdominal aorta banding vs Sham-operated rats
Design
Preclinical
Follow-up
7 days
Authors
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Supports ET-1 role in pressure-overload hypertrophy; extends in vitro data to in vivo model but leaves clinical translation open.
Does pressure overload via aorta banding increase the production of endothelin-1 in the hypertrophied rat heart?
Endogenous endothelin-1 production is increased in the hypertrophied left ventricle of rats subjected to pressure overload, suggesting its involvement in the development of cardiac hypertrophy.
Yorikane et al. (1993) studied this question.
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